Plain-English translation of NCT07163221 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
The At-Home ULTRA Study is testing a device called the MINI system that delivers ultrasound stimulation to your spleen to help reduce inflammation from rheumatoid arthritis. This treatment is being studied for people whose arthritis hasn't improved enough with conventional medications. The study will compare people who receive the active treatment to those who receive a placebo (sham) treatment over 12 weeks, then follow everyone for another 12 weeks to see how long the benefits last.
Many people with rheumatoid arthritis don't respond well enough to current medications, or can't tolerate them. This trial exists to explore whether stimulating the spleen with ultrasound—a completely non-invasive approach you can do at home—might offer a new way to control inflammation and improve symptoms.
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You would visit the study site at the start (Week 0) and then use the MINI ultrasound device at home for 20 minutes once daily. You'll be randomly assigned to receive either active ultrasound treatment, a different active treatment setting, or a sham (inactive) treatment. After 12 weeks, researchers will check how you're doing, and those who received the sham treatment will be switched to receive active treatment. The entire study lasts 28 weeks, with check-ins to monitor your arthritis symptoms and how well the treatment is working.
AI-generated summary from trial data · Jun 17, 2026 · Not medical advice
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