Immune cell treatment to prevent cancer in Lynch syndrome carriers

This is an early-stage study testing a new approach called dendritic cell therapy to help prevent cancer in people with Lynch syndrome. Researchers will take immune cells from your own blood, prepare them in a lab to recognize cancer-causing mutations, and give them back to you as a personalized treatment. The goal is to see if this approach is safe and whether it helps your immune system stop cancer before it starts.

People with Lynch syndrome have a significantly higher risk of developing certain cancers because they carry a mutation in genes that normally repair DNA mistakes. Current care focuses on catching cancer early through frequent screening, but there is no way to prevent it from developing. This study explores whether training your own immune system to recognize and attack precancerous cells could offer a new way to prevent cancer altogether.