Testing a vision implant for advanced age-related macular degeneration

Plain-English translation of NCT07164378 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

The PERSPECTIVE Study is testing the SING IMT™ Prosthesis, a small implant designed to help restore central vision in people with advanced age-related macular degeneration (AMD). AMD is a condition where the center of your vision gradually deteriorates, making it hard to read or recognize faces. This trial will compare two surgical approaches: placing the implant on top of your existing lens implant, or replacing the existing lens implant entirely.

Advanced AMD causes severe central vision loss that current treatments cannot fully restore. This trial exists to see if this new implant can meaningfully improve vision and quality of life for people with late-stage AMD who have already had cataract surgery.

Do you qualify?

You likely qualify if…

you are 55 years of age or older
you have been diagnosed with advanced AMD in both eyes with specific patterns of vision loss (geographic atrophy or scarring involving the center of your vision)
you had cataract surgery with a lens implant in both eyes at least 6 months ago
your vision falls between 20/80 and 20/800 in both eyes (moderately to profoundly impaired)
you are willing to participate in training to learn how to use the implant after surgery
your eye structure (anterior chamber depth and corneal cell count) meets certain measurements required for the implant

You likely don't qualify if…

you have had active choroidal neovascularization (abnormal blood vessel growth in the eye) or treatment for it within the past 6 months
you have diabetes-related eye disease, retinal detachment, or certain other eye conditions affecting both eyes
you have had significant eye inflammation, infection, or had certain types of eye surgery (vitrectomy) in the past
you have uncontrolled glaucoma or high eye pressure (over 22 mmHg) before surgery
you have significant communication difficulties or severe neurological conditions that would prevent you from following instructions

What participation looks like

If you enroll, you will be randomly assigned to one of two groups: one group will receive the implant placed in front of their existing lens implant, and the other will have their existing lens implant removed and replaced with the new implant. You will undergo eye surgery on one eye, followed by a training program to learn how to use the implant and adapt to your improved vision. You will have multiple follow-up visits to monitor your healing and vision improvements over time.

AI-generated summary from trial data · Jun 3, 2026 · Not medical advice

Trial locations(12 sites)

France

Centre d'Ophtalmologie Paradis-Monticelli, Marseille

Hélios Ophtalmologie, Saint-Jean-de-Luz

CHU de Strasbourg, Strasbourg

Germany

Asklepios Augenklinik Nord-Heidberg, Hamburg

Augenklinik Sulzbach, Sulzbach