Testing compression stockings to prevent nerve damage from cancer treatment

This study is testing whether medical-grade compression stockings can help prevent peripheral neuropathy—a type of nerve damage that causes tingling, numbness, and pain in the hands and feet—in patients receiving antibody-drug conjugates (ADCs) for advanced cancers like urothelial carcinoma. You would wear a compression stocking on one foot during your cancer treatment while leaving the other foot uncovered, allowing researchers to compare how well the stocking protects against nerve damage.

Antibody-drug conjugates are effective cancer treatments, but they often cause painful nerve damage in the feet and hands as a side effect. Researchers want to see if compression stockings—which improve blood flow and reduce stress on nerves—might prevent or reduce this damage and help patients maintain their quality of life during treatment.