Plain-English translation of NCT07169123 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Crohns Disease research guide →Researchers at McMaster University are trying to understand what triggers inflammation in Crohn's disease by looking at two specific things: how much sodium (salt) people eat and the enzymes present in their stool. This study will follow 300 people with Crohn's disease for 2 years, collecting information about diet, blood tests, and stool samples to see if there's a connection between salt intake, gut bacteria, and disease activity.
Currently, doctors don't fully understand why some people with Crohn's disease have more inflammation than others, even when on similar treatments. If researchers can identify that salt intake or certain gut enzymes play a role, it could lead to new dietary or medical approaches to help manage the disease better.
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In Phase 1, you would visit the clinic once a year for 2 years (with extra visits if you have a disease flare). At each visit, you'll answer questions about your diet, provide blood and urine samples, and submit a stool sample. Some participants will then be invited to Phase 2, where you'll have more frequent visits over 2 weeks, track your diet closely, and have a colonoscopy with biopsies. After Phase 2, you'll return to the regular Phase 1 schedule.
AI-generated summary from trial data · Aug 6, 2026 · Not medical advice
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