Plain-English translation of NCT07170176 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Some people are born with a small opening between two chambers of the heart called a patent foramen ovale (PFO). Recent research suggests this opening might be connected to migraine headaches, especially migraines with visual symptoms. This study is testing whether closing this opening with a minimally invasive procedure can reduce how often and how severely migraines occur.
While doctors have noticed that some migraine patients also have this heart opening, they don't fully understand the connection or whether closing it really helps long-term. This trial aims to answer that question and learn more about how the procedure might affect the brain's cleaning system, which may play a role in migraines.
You likely qualify if…
You likely don't qualify if…
If you qualify for the migraine group, you would receive the heart closure procedure and then return for follow-up visits to report your migraine symptoms and have brain imaging scans before and after treatment. If you are in the comparison group (people with the heart opening but no migraines), you would complete the same assessments and imaging but would not have the procedure. All participants would be tracked over time to see how symptoms and brain function change.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
China