A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA) — Stella
Phase 3 — Large-scale testing across thousands of people, comparing the new treatment against current standard treatments.
(307 sites) United States
Alaska Oncology and Hematology, Anchorage, Alaska Ironwood Cancer & Research Centers, Chandler, Arizona Mayo Clinic in Arizona - Phoenix, Phoenix, Arizona The University of Arizona Cancer Center - North Campus, Tucson, Arizona Highlands Oncology Group, Springdale, Arkansas City of Hope, Duarte, California Marin Cancer Care, Greenbrae, California Chao Family Comprehensive Cancer Center and Ambulatory Care (CIACC) - Irvine, Irvine, California City of Hope Orange County Lennar Foundation Cancer Center, Irvine, California Moores Cancer Center, La Jolla, California USC/Norris Comprehensive Cancer Center, Los Angeles, California Hoag Memorial Hospital Presbyterian, Newport Beach, California Kaiser Permanente Oakland, Oakland, California Profound Research LLC, Oceanside, California University of California, Irvine (UCI) Health - UC Irvine Medical Center, Orange, California Desert Regional Medical Center, Palm Springs, California Stanford Cancer Center, Palo Alto, California Kaiser Permanente, Roseville, California Kaiser Permanente, San Francisco, California UCSF Medical Center at Mission Bay, San Francisco, California Kaiser Permanente, Santa Clara, California UCLA Hematology/Oncology - Parkside, Santa Monica, California Providence Medical Foundation, Santa Rosa, California Kaiser Permanente, Vallejo, California Kaiser Permanente Walnut Creek, Walnut Creek, California Cancer Centers of Colorado St. Mary's Regional Hospital, Grand Junction, Colorado MedStar Washington Hospital Center, Washington D.C., District of Columbia Clermont Oncology Center, Clermont, Florida Mayo Clinic in Florida, Jacksonville, Florida Mid Florida Hematology and Oncology Center, Orange City, Florida City of Hope National Medical Center, Atlanta Cancer Center, Newnan, Georgia Summit Cancer Care, PC, Savannah, Georgia Kaiser Permanente Moanalua Medical Center, Honolulu, Hawaii City of Hope, Chicago, Chicago, Illinois Northwestern Memorial Hospital, Chicago, Illinois University of Illinois at Chicago, Chicago, Illinois Accellacare of Duly, Lisle, Illinois Indiana University Health University Hospital, Indianapolis, Indiana Deaconess Chancellor Center for Oncology, Newburgh, Indiana University of Iowa, Iowa City, Iowa Saint Elizabeth Medical Center Edgewood, Edgewood, Kentucky Our Lady of the Lake RMC, Baton Rouge, Louisiana American Oncology Partners, PA, Bethesda, Maryland James M Stockman Cancer Institute, Frederick, Maryland Mass General Cancer Center, Boston, Massachusetts Dana-Farber Cancer Institute, Boston, Massachusetts Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Medical Center, Milford, Massachusetts Dana-Farber/Brigham and Women's Cancer Center - South Shore Hospital, South Weymouth, Massachusetts Profound Research LLC, Sterling Heights, Michigan Mayo Clinic in Rochester, Minnesota, Rochester, Minnesota North Mississippi Hematology and Oncology Associates, Tupelo, Mississippi Saint Luke's Cancer Institute, Kansas City, Missouri Oncology Hematology Associates, Springfield, Missouri Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire Jefferson Health - Cherry Hill, Cherry Hill, New Jersey Sidney Kimmel Cancer Center - Washington Township, Sewell, New Jersey Atlantic Health System Overlook Medical Center, Summit, New Jersey Memorial Sloan Kettering Cancer Center, New York, New York Messino Cancer Centers, Asheville, North Carolina WakeMed Cancer Care - Waverly Hematology & Medical Oncology, Cary, North Carolina University of North Carolina Medical Center, Chapel Hill, North Carolina Carolina Cancer Research Center, Wilson, North Carolina Cleveland Clinic Akron General, Akron, Ohio Gabrail Cancer Center, Canton, Ohio Fairview Hospital, Cleveland, Ohio The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T, Columbus, Ohio Cleveland Clinic - Hillcrest Hospital, Mayfield Heights, Ohio Good Samaritan Regional Medical Center, Corvallis, Oregon Oncology Associates of Oregon, Eugene, Oregon Oregon Health and Science University, Portland, Oregon St. Luke's University Health Network, Bethlehem, Pennsylvania University of Pennsylvania Hospital, Philadelphia, Pennsylvania Thomas Jefferson University - Clinical Research Institute, Philadelphia, Pennsylvania Jefferson Hospital Northeast, Philadelphia, Pennsylvania Asplundh Cancer Pavilion, Willow Grove, Pennsylvania Medical University of South Carolina, Charleston, South Carolina Sarah Cannon Research Institute SCRI, Nashville, Tennessee Nashville General Hospital, Nashville, Tennessee Hendrick Medical Center, Abilene, Texas World Research Link, Baytown, Texas Parkland Health and Hospital System, Dallas, Texas USO - Texas Oncology, Dallas, Texas UT Southwestern Medical Center, Dallas, Texas Texas Oncology - West Texas, El Paso, Texas The University of Texas MD Anderson Cancer Center, Houston, Texas Houston Methodist Hospital, Houston, Texas Oncology Consultants P.A., Houston, Texas Nova Oncology, McAllen, Texas Texas Oncology - San Antonio Medical Center, San Antonio, Texas US Oncology Research Network, The Woodlands, Texas Tranquility Research, Webster, Texas Utah Cancer Specialists, Salt Lake City, Utah Virginia Cancer Specialists, Fairfax, Virginia Swedish Cancer Institute - Edmonds, Edmonds, Washington Providence Regional Cancer Partnership, Everett, Washington UW Medicine Valley Medical Center, Renton, Washington Swedish Medical Center, Seattle, Washington Deaconess Hospital, Spokane, Washington Cancer Care Northwest - Vercler, Spokane Valley, Washington MultiCare Health System, Tacoma, Washington North Star Lodge, Yakima, Washington ThedaCare Physicians - Appleton North, Appleton, Wisconsin Argentina
Investigaciones Clinicas Moleculares (ICM), Buenos Aires Centro Oncologico Korben, Buenos Aires Hospital Medico Policial Churruca-Visca, Buenos Aires Organizacion Medica de Investigacion, Buenos Aires Fundación Innovaciencia, Rosario Hospital Provincial del Centenario, Rosario COE (Centro Oncológico de Excelencia), San Juan Instituto San Marcos, San Juan Go Centro Medico San Nicolás, San Nicolás Australia
Ballarat Health Services, Ballarat Central The Prince Charles Hospital, Brisbane St Vincent's Hospital, Darlinghurst Peter MacCallum Cancer Centre, Melbourne Lake Macquarie Private Hospital, Newcastle Macquarie University, North Ryde Goulburn Valley Health, Shepparton St. John of God Subiaco Hospital, Subiaco The Townsville Hospital, Townsville Belgium
Institut Jules Bordet, Anderlecht Jessa Ziekenhuis, Hasselt AZ Groeninge Campus Kennedylaan, Kortrijk CHU UCL Namur/Site Sainte Elisabeth, Namur Clinique Saint Pierre, Ottignies AZ Nikolaas, Sint-Niklaas Brazil
Fundação Pio XII - Hospital de Câncer de Barretos, Barretos Hospital São Domingos, Bequimão Centro de Pesquisa Clínica do Instituto do Câncer do Ceará, Fortaleza Hospital Araújo Jorge, Goiânia Hospital Brasilia, Lago Sul Hospital de Cancer de Londrina, Londrina Instituto Atena de Pesquisa Clinica - Mossoró, Mossoró Liga Norte Riograndense Contra o Câncer, Natal Hospital São Lucas da PUCRS, Porto Alegre Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA, Rio de Janeiro Instituto do Cancer Arnaldo Vieira de Carvalho, São Paulo Icesp - Instituto Do Câncer Do Estado de São Paulo, São Paulo Hospital Santa Catarina - Paulista, São Paulo
Canada
Hamilton Health Sciences-Juravinski Cancer Centre, Hamilton CHU de Québec-Université Laval, Hôpital du Saint-Sacrement, Québec Princess Margaret Cancer Centre, Toronto China
Anyang Cancer Hospital, Anyang Beijing Cancer hospital, Beijing The First Hospital of Jilin University, Changchun The First People's Hospital of Changde City, Changde Xiangya Hospital Central South University, Changsha Sichuan Provincial People's Hospital, Chengdu Deyang City People's Hospital, Deyang Fujian Cancer Hospital, Fuzhou Fujian Medical University Union Hospital, Fuzhou Fujian Sun Yat-sen University Cancer Center, Guangzhou Guangdong Provincial People's Hospital, Guangzhou Harbin Medical University Cancer Hospital, Harbin Jiangmen Center Hospital, Jiangmen France
Sainte Catherine Institut du Cancer Avignon Provence, Avignon Clinique Victor Hugo Le Mans, Le Mans Hopital Prive Jean Mermoz, Lyon Centre de Cancérologie du Grand Montpellier, Montpellier Institut Jean Godinot, Reims Institut Curie - site Saint-Cloud, Saint-Cloud Institut de Cancérologie de l'Ouest, Saint-Herblain Oncopole Claudius Regaud, Toulouse Institut de Cancérologie de Lorraine Alexis Vautrin, Vandœuvre-lès-Nancy Gustave Roussy, Villejuif Germany
Charité Universitaetsmedizin Berlin - Campus Mitte, Berlin Marienhospital Bottrop, Bottrop Universitaetsklinikum Koeln, Cologne Städtisches Klinikum Dessau, Dessau Onkologiezentrum Donauwörth, Donauwörth Universitaetsklinikum Carl Gustav Carus Dresden, Dresden MVZ Medical Center Düsseldorf GmbH, Düsseldorf Universitaetsklinikum Erlangen, Erlangen Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen Agaplesion Markus Krankenhaus, Frankfurt Universitaetsklinikum Freiburg, Freiburg im Breisgau Private Practice - Dr. Helmut Oettle und Prof.Dr.med. Frank Mayer, Friedrichshafen Greece
Agios Savvas Regional Cancer Hospital, Athens Aretaieio Hospital, Athens Attikon General University Hospital, Chaïdári University General Hospital of Heraklion, Heraklion University Hospital of Ioannina, Ioannina University General Hospital of Larissa, Larissa University Hospital of Patras, Pátrai European Interbalkan Medical Center, Thessaloniki European Interbalkan Medical Center, Thessaloniki European Interbalkan Medical Center, Thessaloniki Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna Azienda Ospedaliera Universitaria Careggi, Florence Ospedale San Martino, Genova Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola Istituto Europeo di Oncologia IRCCS, Milan Humanitas Istituto Clinico Catanese, Misterbianco Fondazione IRCCS San Gerardo dei Tintori, Monza Azienda Ospedaliera Universitaria Federico II, Naples Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples Istituto Oncologico Veneto IRCCS, Padova Fondazione Policlinico Universitario Agostino Gemelli, Roma Japan
Juntendo University Hospital, Bunkyō City Chiba cancer center, Chiba National Hospital Organization Kyushu Cancer Center, Fukuoka Kyushu University Hospital, Fukuoka Fukushima Medical University, Fukushima Saitama Medical University International Medical Center, Hidaka Kansai Medical University Hospital, Hirakata Hiroshima City Hospital, Hiroshima Hiroshima University Hospital, Hiroshima Sagara Hospital, Kagoshima Kanazawa Medical University Hospital, Kahoku-gun The Cancer Institute Hospital of JFCR, Kōtoku Kyoto University Hospital, Kyoto South Korea
Soon Chun Hyang University Cheonan Hospital, Cheonan-si Kyungpook National University Chilgok Hospital, Deagu Gangnam Severance Hospital, Yonsei University Health System, Gangnam-gu Yeungnam Univeristy Medical Center, Gyeongsan-si Inha University Hospital, Incheon Korea University Anam Hospital, Seoul Seoul National University Hospital, Seoul Severance Hospital, Yonsei University Health System, Seoul Asan Medical Center, Seoul Samsung Medical Center, Seoul Spain
Hospital Infanta Cristina, Badajoz Hospital Universitari Dexeus, Barcelona Hospital Universitari Vall d'Hebron, Barcelona Hospital San Pedro de Alcántara, Cáceres Hospital Universitario Donostia, Donostia / San Sebastian Hospital Universitario San Cecilio, Granada Instituto Catalan de Oncologia - Hospital Duran i Reynals, Hospitalet Complejo Hospitalario de Jaén, Jaén Hospital Insular de Gran Canaria, Las Palmas de Gran Canaria Hospital Universitario Arnau de Vilanova de Lleida, Lleida Hospital Beata María Ana, Madrid Hospital General Universitario Gregorio Marañon, Madrid Hospital Universitario Ramón y Cajal, Madrid
Taiwan
Taichung Veterans General Hospital, Taichung National Cheng Kung University Hospital, Tainan Chi Mei Medical Center, Tainan National Taiwan University Hospital, Taipei Taipei Veterans General Hospital, Taipei Turkey (Türkiye)
Baskent University Dr. Turgut Noyan Research and Training Center, Adana Adana City Hospital, Adana Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi, Ankara Ankara University Health Practice and Research Hospitals, Ankara Ege Universitesi Hastanesi, Bornova Trakya University, Edirne Koç Üniversitesi Hastanesi, Istanbul Yeditepe Üniversitesi Koşuyolu Hastanesi, Istanbul United Kingdom
Huddersfield Royal Infirmary, Huddersfield St Bartholomew's Hospital, London Royal Marsden Hospital (Sutton), London Royal Marsden Hospital (Chelsea), London The Christie NHS Foundation Trust, Manchester Derriford Hospital, Plymouth Worcestershire Royal Hospital, Worcester
Key details Sponsor
Eli Lilly and Company
Enrollment target
~920 participants
Primary completion
May 2029
Clínica de Pesquisas e Centro de Estudos em Oncologia Ginecológica e Mamária Ltda, São Paulo
IBCC - Núcleo de Pesquisa e Ensino, São Paulo The first affiliated hospital of Ningbo university, Ningbo
Fudan University Shanghai Cancer Center, Shanghai Cancer Hospital of Shantou University Medical College, Shantou The First Hospital of China Medical University, Shenyang Tianjin Medical University Cancer Institute & Hospital, Tianjin Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan Tongji Hospital Tongji Medical,Science & Technology, Wuhan Central Hospital of Guangdong Provincial Agricutural Reclamation, Zhanjiang Mammazentrum HH - Krankenhaus Jerusalem, Hamburg
Universitaetsklinikum des Saarlandes, Homburg Universitätsklinikum Leipzig, Leipzig Klinikum Ludwigsburg, Ludwigsburg Universitätsmedizin Johannes Gutenberg Universität Mainz, Mainz Klinikum der Ludwig-Maximilians-Universitaet Muenchen, München Klinikum Ernst von Bergmann, Potsdam SRH Zentralklinikum Suhl, Suhl Helios HSK Wiesbaden, Wiesbaden Marien Hospital Witten, Witten HELIOS Klinikum Wuppertal, Wuppertal Nagoya City University Hospital, Nagoya
Nakagami Hospital, Okinawa Gunma Prefectural Cancer Center, Otashi Saitama Red Cross Hospital, Saitama Hokkaido University Hospital, Sapporo Tohoku University Hospital, Sendai Showa Medical University Hospital, Shinagawa City Shizuoka General Hospital, Shizuoka The University of Osaka Hospital, Suita Tsukuba University Hospital, Tsukuba Kanagawa cancer center, Yokohama Hospital Clinico San Carlos, Madrid
Hospital Universitario 12 de Octubre, Madrid Hospital Universitario HM Sanchinarro, Madrid Hospital Universitario Virgen de la Victoria, Málaga Hospital Universitari Son Espases, Palma Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca Hospital Universitario de Canarias, San Cristóbal de La Laguna CHUS - Hospital Clinico Universitario, Santiago de Compostela Hospital Universitario Virgen Macarena, Seville Hospital Universitario Virgen Del Rocio, Seville Fundación Instituto Valenciano de Oncología, Valencia Hospital Clinico de Valencia, Valencia Hospital Arnau de Vilanova, Valencia Hospital Clínico Universitario Lozano Blesa, Zaragoza