Blood cell function tests to improve diagnosis of lung high blood pressure

Plain-English translation of NCT07176260 on ClinicalTrials.gov ↗ · Source last updated September 2025 · Translation generated July 2026 · How we translate trials

What is this trial?

Researchers want to understand whether simple blood tests measuring how well your blood cells work and how much stress they're under can help doctors better diagnose and predict the course of pre-capillary pulmonary hypertension (a condition where blood pressure in the lungs is abnormally high). This study will follow 120 patients for 3 years, collecting blood samples several times a year to see if these blood measurements match up with standard heart and lung tests and can guide personalized treatment plans.

Currently, doctors diagnose this condition using procedures like heart catheterization and echocardiograms, but doctors need better ways to spot early warning signs and predict which patients will get worse. This research hopes to find simpler blood tests that could catch disease progression earlier and help tailor care to individual patients.

Do you qualify?

You likely qualify if…

you are 18 years old or older
you have been diagnosed with pre-capillary pulmonary hypertension confirmed by a heart catheterization procedure
your diagnosis falls into one of the three main types: pulmonary arterial hypertension, pulmonary hypertension linked to chronic lung disease, or chronic blood clots in the lungs
you are scheduled for routine follow-up care or testing at the study hospital
you are willing and able to give informed consent to participate

You likely don't qualify if…

you have a different type of pulmonary hypertension (postcapillary type)
you have severe anemia or a bleeding disorder that would make blood draws unsafe
you are already enrolled in another clinical trial that could interfere with the blood cell and stress measurements
you are pregnant or breastfeeding
you are unable or unwilling to provide informed consent

What participation looks like

You will visit the study center for routine blood draws up to three times per year over 3 years—no extra clinic visits are needed since the blood samples are collected during your regular appointments for diagnosis and follow-up care. Each blood draw will be analyzed to measure how your blood cells function and how much oxidative stress they're experiencing. Researchers will then compare your blood test results with your standard heart and lung tests (like echocardiograms, heart catheterizations, and walking tests) to see if the blood markers can predict how your condition will progress.

AI-generated summary from trial data · Jul 16, 2026 · Not medical advice

Blood cell function tests to improve diagnosis of lung high blood pressure

What is this trial?

Do you qualify?

What participation looks like

Trial locations