Using a urine DNA test to guide bladder cancer follow-up care

This trial is testing whether a urine DNA test—a simple, non-invasive test that detects cancer-related changes in your urine—can help doctors decide when you need a cystoscopy (a camera exam of your bladder) for follow-up care. After surgery for high-risk bladder cancer, you normally need regular cystoscopies to check for cancer returning, but these exams can be uncomfortable and sometimes risky. This study hopes to show that combining the urine DNA test with cystoscopy can safely reduce the number of unnecessary camera exams while still catching any cancer that comes back.

High-risk bladder cancer often comes back, so patients need frequent and invasive cystoscopy exams to monitor for recurrence. This trial addresses the problem that these repeated exams are uncomfortable, expensive, and sometimes cause infection or bleeding—so doctors and patients are looking for a simpler, more accurate way to guide follow-up care.