Plain-English translation of NCT07180563 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing whether berberine hydrochloride, when combined with doxycycline (a common antibiotic), can better treat chronic endometritis — a condition where the lining of the uterus becomes persistently inflamed. Half of the participants will take both medications together for 14 days, while the other half will take only the antibiotic. The study will compare how well each approach works by measuring whether the inflammation goes away completely.
Currently, doxycycline alone is the standard treatment for this condition, but it doesn't work for everyone. Doctors hope that adding this medication might improve cure rates and reduce how often the condition comes back.
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If you join this study, you will first have a biopsy procedure to confirm your diagnosis. Then you'll be randomly assigned to one of two groups: one group takes both berberine and doxycycline by mouth for 14 days, while the other takes doxycycline alone. After you finish the 14-day treatment, doctors will check whether the inflammation in your uterus has cleared up, likely using another biopsy to see if the condition has resolved.
AI-generated summary from trial data · Aug 26, 2026 · Not medical advice
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