Plain-English translation of NCT07188246 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Breast Cancer research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a new combination approach for advanced breast cancer that hasn't been treated yet. You would receive focused radiation therapy to your tumor along with injections of pembrolizumab (an immune-boosting medication already approved for some cancers), followed by standard chemotherapy. The goal is to see if this medication and radiation work together to better prepare your immune system to fight the cancer.
Earlier research showed that targeted radiation can activate the immune system and make tumors more responsive to immune therapy. This trial is designed to find out whether adding this medication to radiation therapy further boosts the immune response and improves outcomes before you receive chemotherapy.
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You would receive focused radiation therapy to your breast tumor on an outpatient basis, and receive two injections of the medication during this time—all before you start standard chemotherapy. Your doctor will take tissue samples before and after treatment to study how your immune system responds. You'll have regular follow-up visits to monitor your health, side effects, and how well the treatment is working.
AI-generated summary from trial data · Jul 15, 2026 · Not medical advice
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