Plain-English translation of NCT07189936 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This research trial is testing a medication called 2-HOBA in people who have long COVID and POTS, a condition where your heart rate spikes when you stand up. Researchers believe that after COVID infection, some patients develop an overactive immune response that doesn't calm down, and this medication may help reduce that harmful immune activity. The study will measure whether the medication improves symptoms like dizziness and rapid heartbeat.
People with long COVID and POTS have an immune system that stays overstimulated long after the initial infection, causing ongoing symptoms and blood vessel problems. This medication is designed to reduce the harmful products that fuel this immune overactivity, offering a new way to help patients recover.
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If you join this study, you will take the study medication (or a placebo) once daily for 28 days. You'll visit the research clinic for tests including heart rate measurements during standing and head-up tilt testing (where you lie on a special table that tilts upward). Blood samples will be taken to measure immune markers. The study team will track how the medication affects your symptoms and immune response over this one-month period.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
United States