Testing a new injection to help people with severe, hard-to-control lung disease

Plain-English translation of NCT07190209 on ClinicalTrials.gov ↗ · Source last updated June 2026 · Translation generated June 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This trial is testing a new medication called to see if it can help people with severe COPD—a progressive lung disease that makes breathing difficult—especially those whose symptoms aren't controlled by their current medicines. About 942 people will receive either or a placebo (a dummy injection) through shots under the skin over 48 weeks. Researchers want to find out if this medication reduces flare-ups and improves breathing and quality of life for people with a specific type of COPD.

Many people with COPD continue to have frequent, serious flare-ups even when taking three different inhalers together. This medication is being tested to see if it offers a new way to better control symptoms and prevent these flare-ups in patients whose current treatments aren't working well enough.

Do you qualify?

You likely qualify if…

you are between 40 and 80 years old
you have been diagnosed with COPD for at least one year
you are a current or former smoker with at least a 10 pack-year smoking history
you are already taking three COPD medications (a combination therapy) for at least 12 weeks
you have had at least two moderate or one severe COPD flare-up in the past year despite your current medicines
you have a specific type of COPD with higher levels of eosinophils (a type of white blood cell) in your blood

You likely don't qualify if…

you have asthma or a diagnosis of both asthma and COPD overlapping together
you use long-term oxygen therapy at high flow rates or need supplemental oxygen to maintain safe oxygen levels at rest
you are currently taking certain long-term antibiotics or other medications for COPD that haven't been stable for at least 6 months
you have received another biologic medication or strong immune-suppressing drug in the past 4 months
you have active tuberculosis or a history of cancer

What participation looks like

You would come to a research clinic and receive shots (injections under the skin) of either the new medication or a placebo every few weeks for 48 weeks. You'll be randomly assigned to one of three groups—two different dosing schedules of the medication or placebo—and neither you nor the researchers will know which group you're in. During the study, you'll have regular clinic visits to check your lung function, track your symptoms, and report any side effects or flare-ups.

AI-generated summary from trial data · Jun 26, 2026 · Not medical advice

Testing a new injection to help people with severe, hard-to-control lung disease

What is this trial?

Do you qualify?

What participation looks like

Trial locations