Plain-English translation of NCT07191392 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depressive Disorder research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a treatment called Temporal Interference Stimulation (TIS), which uses mild electrical stimulation to target specific areas of the brain involved in depression. Researchers want to see if this treatment can help improve mood and reduce depression symptoms. The study will compare people who receive real stimulation to those who receive a placebo (sham) stimulation to understand whether the treatment truly works.
Depression affects many people and current treatments don't work for everyone. This trial exists to explore whether this type of brain stimulation could be a new option for people struggling with depression who may not have found relief with other treatments.
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If you join this study, you would receive 10 to 14 sessions of brain stimulation (either real or placebo), with each session lasting about 30 minutes. Before and after your treatment sessions, you'll complete brain imaging scans (MRI) and take several tests to measure mood, memory, sleep, and thinking. The whole study involves visits to the hospital for assessments and stimulation sessions over a period of several weeks.
AI-generated summary from trial data · Jul 2, 2026 · Not medical advice
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