Plain-English translation of NCT07193901 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing (R)-Ketamine Hydrochloride Nasal Spray—a medication being developed to rapidly reduce depression and suicidal thoughts—in people with major depressive disorder. Researchers want to see if this medication works quickly to ease symptoms and make it safer for people in crisis. The study will also track how the medication moves through your body and any side effects.
When someone is experiencing severe depression with suicidal thoughts, they need help fast—standard antidepressants can take weeks to work. This trial exists to see if this new treatment can provide rapid relief during a mental health crisis, filling an urgent gap in care.
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You would be randomly assigned to receive either the medication or a placebo nasal spray at different doses. You would use the nasal spray as instructed during study visits, where researchers would check your depression and suicidal thoughts regularly and monitor you for any side effects. The study involves multiple doses over time, with visits to assess how well the treatment is working and how your body is responding to it.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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