Testing a supplement with and without a diabetes medication

Plain-English translation of NCT07195994 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing a dietary supplement called AMPK Charge+® to see how well it helps control blood sugar in people with prediabetes or type 2 diabetes. Some participants will take the supplement alone, while others will take it along with semaglutide injections (a medication already approved for diabetes). The study will measure changes in blood sugar levels over 12 weeks to compare how well each approach works.

Semaglutide is an effective diabetes medication, but researchers want to know whether combining it with this supplement might work even better, or whether the supplement alone could be a helpful option for people who need diabetes treatment.

Do you qualify?

You likely qualify if…

you are 18 years old or older
you have been diagnosed with prediabetes (with an HbA1c between 6.0–6.5%) or type 2 diabetes (with an HbA1c between 6.5–7.5%) and are not currently on diabetes medication
you have not gained or lost more than 5 kg (about 11 pounds) of body weight in the three months before entering the study
you are willing to keep your diet, exercise, medications, and other habits as stable as possible during the 12-week study
you are able to attend clinic visits and complete questionnaires and daily records
if you can become pregnant, you agree to use a reliable form of birth control for the entire study and have a negative pregnancy test at the start

You likely don't qualify if…

you are pregnant, breastfeeding, or planning to become pregnant during the study
you have a personal or family history of medullary thyroid cancer or MEN 2 syndrome
you have type 1 diabetes or have experienced diabetic ketoacidosis
you have significant liver or kidney disease, unstable high blood pressure, or a recent serious heart problem (within the past 6 months)
you have a significant digestive tract disease or an allergy to any of the supplement ingredients

What participation looks like

If you join this study, you will be randomly assigned to receive either the AMPK Charge+® supplement alone or the supplement combined with semaglutide injections. You will take or use your assigned treatment for 12 weeks (84 days) while visiting the clinic for blood tests and check-ups to measure your blood sugar levels. Throughout the study, you will be asked to keep your lifestyle, diet, and exercise habits as consistent as possible and to complete some questionnaires about how you're feeling.

AI-generated summary from trial data · Jun 13, 2026 · Not medical advice

Testing a supplement with and without a diabetes medication

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)