Recruiting

Testing a new medication for kidney damage from lupus

Plain-English translation of NCT07201129 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated June 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This clinical trial is testing whether a medication called can help treat active kidney damage caused by lupus (a condition where the immune system attacks the body's own tissues). You would take or a placebo (a pill with no active drug) every day for about 18 months, alongside your regular lupus treatments. Researchers want to learn if this medication improves kidney function and how safe it is.

Lupus can seriously damage the kidneys, and current treatments don't work well enough for everyone. This trial is exploring whether this medication might offer a new option to protect kidney function and reduce kidney damage in people with lupus.

Do you qualify?

You likely qualify if…

you have been diagnosed with systemic lupus erythematosus (SLE) according to established medical criteria
you have had a kidney biopsy within the last 6 months showing active lupus-related kidney inflammation (Class III, IV, or V)
you have significant protein in your urine (≥ 1 mg/mg on a 24-hour collection), showing active kidney disease
your kidney function is at a certain level (eGFR ≥ 15 mL/min/1.73 m²) and stable enough for the trial
you are willing to take standard lupus treatments (mycophenolate and corticosteroids) as required by the study

You likely don't qualify if…

you have severe active lupus affecting your brain or nervous system
you have other kidney diseases besides lupus (such as diabetic kidney disease) that could confuse the results
you have kidney disease so advanced that you need dialysis or a transplant
you are pregnant or planning to become pregnant during the trial and the 6 months after stopping the medication
you have certain heart rhythm problems

What participation looks like

You would take either the medication or a placebo pill once daily for about 18 months (76 weeks), alongside your regular lupus treatments. You would visit the clinic every 1 to 3 months for checkups, blood tests, and urine tests to see how your kidneys are responding. If you are capable of becoming pregnant, you would also need monthly pregnancy tests and must use effective contraception throughout the trial.

AI-generated summary from trial data · Jun 21, 2026 · Not medical advice

Testing a new medication for kidney damage from lupus

What is this trial?

Do you qualify?

What participation looks like

Trial locations