Fluids plus medication versus medication alone to prevent pancreas inflammation

You may be scheduled for extracorporeal shock wave lithotripsy (ESWL), a procedure that uses shock waves to break up stones in your pancreas. This trial tests whether combining aggressive intravenous fluid treatment with indomethacin—a medication given by rectal suppository—prevents pancreatitis (pancreas inflammation) better than using indomethacin alone. The goal is to find the safest, most effective way to protect you from serious complications after this procedure.

Pancreatitis is a serious complication that can happen after shock wave treatment of pancreatic stones. Doctors already use indomethacin to help prevent it, but they want to know if adding aggressive fluid replacement improves protection and leads to better outcomes for patients.