Plain-English translation of NCT07202949 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
EAT-UP is testing whether using a standard treatment dose of antibiotics (such as cefalexin, nitrofurantoin, or trimethoprim) combined with methenamine hippurate—a urinary antiseptic that helps protect the bladder—works better than the current standard care for women with chronic urinary tract infections. The trial will compare this combination approach to either a low-dose antibiotic alone or methenamine hippurate alone, depending on what your doctor thinks is best for you.
Chronic urinary tract infections are painful and disruptive, and current treatment options don't work well enough for many women. Researchers want to see if using a higher antibiotic dose combined with a urinary antiseptic can provide better, longer-lasting relief than what's available today.
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If you join this trial, you will be randomly assigned to receive either a combination of higher-dose antibiotic plus methenamine hippurate, or standard treatment (low-dose antibiotic or methenamine hippurate alone). You'll take your assigned medication for 12 weeks and attend clinic visits every 4 weeks for check-ups, blood tests, urine samples, and swabs. Your doctor will choose which specific antibiotic or treatment is best for your individual situation.
AI-generated summary from trial data · Jun 26, 2026 · Not medical advice
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