Recruiting

Testing a new drug combination to shorten tuberculosis treatment

Plain-English translation of NCT07209761 on ClinicalTrials.gov ↗ · Source last updated May 2026 · Translation generated June 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This trial is testing a new drug combination that includes quabodepistat for people with drug-resistant tuberculosis — a serious form of TB that doesn't respond to standard antibiotics. The study compares this new medication combination to the current standard treatment, trying to determine if the new approach works better, causes fewer side effects, and may shorten treatment from 6 months to 4 months in some cases.

Current treatments for drug-resistant TB are long, difficult to tolerate, and can cause serious side effects. This medication offers hope for a shorter, safer treatment option that could help more people successfully cure this dangerous infection.

Do you qualify?

You likely qualify if…

you are at least 14 years old and weigh at least 30 kg (about 66 pounds)
you have been diagnosed with drug-resistant pulmonary tuberculosis confirmed by testing
you are able to provide sputum (cough) samples for testing
you commit to using two reliable forms of birth control during treatment and for 12 weeks after if you can become pregnant
you are willing to have an HIV test and, if positive, have your infection well-controlled on antiretroviral medication

You likely don't qualify if…

you have previously taken certain TB medications (bedaquiline, pretomanid, linezolid, or related drugs) for a month or longer within the past 3 months
you have serious liver or kidney problems, or very low blood cell counts
you are pregnant, breastfeeding, or not able to use reliable birth control
you have nerve damage, eye problems, or serious heart conditions
you are currently enrolled in another drug treatment trial

What participation looks like

You will take a combination of medications by mouth daily for either 4 or 6 months, depending on which group you're assigned to and your TB type. You'll visit the clinic regularly for blood tests, chest X-rays, and sputum samples to check how well the treatment is working. After finishing the medication, researchers will follow up with you for several more months to make sure the tuberculosis has been cured and to watch for any delayed side effects.

AI-generated summary from trial data · Jun 3, 2026 · Not medical advice

Testing a new drug combination to shorten tuberculosis treatment

What is this trial?

Do you qualify?

What participation looks like

Trial locations