Plain-English translation of NCT07213934 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing whether combining radiation therapy with (a medication that helps your immune system fight cancer) works better than either treatment alone for people whose head and neck cancer has returned. The study will test two types of radiation—standard radiation therapy and proton therapy—each combined with the medication. Researchers hope this combination will help more patients achieve a major reduction in their tumors before surgery.
Head and neck cancer that comes back after treatment is very difficult to treat and has limited options. This trial exists to see whether adding an immune-boosting medication to radiation therapy can improve outcomes for these patients.
You likely qualify if…
You likely don't qualify if…
If you join, you will receive either standard radiation therapy or proton radiation therapy (the study will determine which you receive), given in 3 sessions before surgery. After radiation, you'll have surgery to remove the cancer. Following surgery, you'll receive (the immunotherapy medication) as part of your follow-up care. The trial has two phases: Phase I tests the safest dose, and Phase II tests whether this combination works better than the medication alone, with about 40 patients total across both phases.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
United States