Oxygen therapy to improve thinking and mood in veterans

Plain-English translation of NCT07214415 on ClinicalTrials.gov ↗ · Source last updated October 2025 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing (HBOT)—a treatment where you breathe pure oxygen in a pressurized chamber—to see if it can help veterans improve their memory, concentration, and emotional well-being. Researchers want to understand whether this treatment can ease symptoms of traumatic brain injury, PTSD, depression, and anxiety, and whether it genuinely makes a difference in how veterans function day-to-day.

Many veterans struggle with lingering effects of brain injuries and trauma that standard treatments alone don't fully resolve. Researchers believe this treatment might help the brain heal by delivering extra oxygen to areas that need it, but they need to test whether it actually works and helps people feel better.

Do you qualify?

You likely qualify if…

you are at least 18 years old and have served in the military
you have been diagnosed with traumatic brain injury, PTSD, anxiety, depression, or a related condition by a trained professional
you have already tried at least one type of therapy (such as prolonged exposure therapy, EMDR, or cognitive behavioral therapy) for your condition
you are currently stable on any mental health medications you may be taking
you are able to read, understand, and sign consent forms and clearly express how you're feeling
your condition significantly affects your work, relationships, or daily functioning

You likely don't qualify if…

you have an untreated collapsed lung or a history of collapsed lung
you have a current or recent severe sinus, upper respiratory, or middle ear infection
you are currently using nicotine, drugs, or have an active substance use disorder
you are experiencing active suicidal thoughts, or symptoms of psychosis or mania
you have lung disease (like COPD or emphysema), uncontrolled diabetes requiring insulin, or active cancer

What participation looks like

You would receive sessions in a pressurized chamber where you breathe pure oxygen—similar to what deep-sea divers use. The study will measure your thinking, mood, and quality of life before and after treatment to see if the therapy helps. You'll need to be able to attend scheduled clinic visits and follow the study plan, and you cannot have received this treatment before.

AI-generated summary from trial data · Jun 2, 2026 · Not medical advice

Trial locations(1 site)

United States

Summit Hyperbarics and Wellness, Boise, Idaho