Plain-English translation of NCT07215520 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a new COVID-19 vaccine called that you inhale through your nose, rather than receiving as a shot in your arm. Researchers want to see if this medication is safe and causes fewer side effects than the standard COVID-19 booster vaccine. The study will compare this new nasal vaccine to the approved mRNA vaccine that many people are already familiar with.
Current COVID-19 vaccines work well but some people experience side effects or prefer not to get shots. This medication is designed to provide protection against COVID-19 while potentially being more comfortable to receive and causing fewer unwanted reactions.
You likely qualify if…
You likely don't qualify if…
If you are enrolled, you will be randomly assigned to receive either the new nasal vaccine plus a placebo injection, or a placebo nasal spray plus the standard COVID-19 booster shot in your arm. You will not know which group you are in (that's the 'double-blind' part). You will need to attend study visits, likely including a screening visit, a vaccination visit, and follow-up visits to check for any side effects or reactions. The study will monitor your safety and ask about how you are feeling after vaccination.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
United States