Testing a new ultrasound device to measure heart stiffness

Plain-English translation of NCT07215715 on ClinicalTrials.gov ↗ · Source last updated October 2025 · Translation generated July 2026 · How we translate trials

What is this trial?

Researchers are testing a new ultrasound device called eMyosound LYRA that can measure how stiff your heart muscle has become. This study will help doctors understand whether this device can reliably detect heart stiffness in people with different types of heart failure, which could help with diagnosis and treatment in the future.

Certain types of heart failure involve the heart muscle becoming stiff, which makes it harder for the heart to work properly. Right now, doctors don't have a simple, reliable way to measure this stiffness, so this new ultrasound device could fill an important gap in how we diagnose and understand these conditions.

Do you qualify?

You likely qualify if…

you are at least 60 years old
you have been diagnosed with heart failure with preserved heart function (your heart pumps normally, but the muscle is stiff) or you are a healthy control participant
your heart has thickened walls (left ventricular hypertrophy) if you have heart failure
you have normal heart rhythm at the time of measurement, even if you have a history of irregular heartbeats
you are able to give informed consent and follow the study procedures

You likely don't qualify if…

you are pregnant or pre-menopausal
you have had a heart attack within the past 30 days
you have a very rapid heart rate (over 130 beats per minute) or active irregular heartbeats at the time of testing
you have had a heart, lung, liver, or kidney transplant or are expecting one within the next year
you have severe kidney disease or are on dialysis

What participation looks like

You will come for a single visit lasting about 2.5 hours at one of three medical centers. During this visit, you will have an ultrasound scan of your heart and liver using the new eMyosound LYRA device—this is painless and non-invasive. The ultrasound will measure how stiff your heart muscle is, and the same scan will be done twice by different technicians to make sure the device gives reliable results each time.

AI-generated summary from trial data · Jul 7, 2026 · Not medical advice

Trial locations(3 sites)

United States

Massachusetts General Hospital, Boston, Massachusetts

Brigham and Women's Hospital, Boston, Massachusetts

Boston Medical Center, Boston, Massachusetts