Testing sealants to prevent fluid leaks after nasal skull surgery

This trial is testing whether using special sealants during nasal skull base surgery—specifically Tisseel (a biological glue) or Adherus (a synthetic polymer)—actually prevents cerebrospinal fluid leaks better than standard surgical closure alone. Right now, surgeons use these sealants routinely, but recent evidence suggests they may not be necessary for all patients, especially those at low risk. This study will help determine which approach works best and is most cost-effective.

Cerebrospinal fluid leaks are a common and serious complication after nasal skull surgery, and surgeons have started using expensive sealants to prevent them. However, recent high-quality research questions whether these products actually improve outcomes, especially for patients who are already at low risk for leaks. This trial will provide clear evidence to guide better, more cost-effective surgical practices.