Plain-English translation of NCT07218380 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This study is testing whether a new medication called can help people with advanced bladder cancer that has spread or cannot be surgically removed. You would take as a pill along with two other cancer medications given through an IV — one called enfortumab vedotin and one called . Half of the participants will receive the new medication, and half will receive a placebo (a pill with no medicine) to see which works better.
Bladder cancer that has spread is very serious, and current treatments don't work well enough for everyone. Researchers believe that the medication being tested might work better when combined with these two existing drugs, especially for people whose cancer has a specific genetic change.
You likely qualify if…
You likely don't qualify if…
You would visit the clinic regularly — likely every few weeks at first — to receive your IV medications and have blood tests and scans to check how your cancer is responding. You would take the medication (or placebo) as a daily pill at home. The study could last up to about 6 years, though your active treatment phase would likely be shorter. Your doctor will monitor you closely for side effects and adjust your care as needed.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
United States