Recruiting

Testing a new medication for hot flashes and aging in women with obesity

Plain-English translation of NCT07218445 on ClinicalTrials.gov ↗ · Source last updated October 2026 · Translation generated August 2026 · How we translate trials

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Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.

What is this trial?

This pilot study is testing whether can help reduce hot flashes in postmenopausal women who live with obesity. Hot flashes — those sudden waves of intense heat, sweating, and discomfort — are a common problem during menopause, and current treatment options don't work well for everyone. Researchers want to see if this medication, combined with lifestyle changes like diet and exercise, might ease these symptoms and even slow down some signs of biological aging.

Many women struggle with persistent hot flashes even after menopause ends, and standard hormone-based treatments aren't suitable or effective for everyone. This medication has already shown promise for weight management; researchers want to explore whether it might also help with hot flashes and aging, offering women a new treatment option.

Do you qualify?

You likely qualify if…

you are a woman between 46 and 60 years old
you have a BMI of 30 or higher (or 27 or higher with related health conditions like high blood pressure or sleep apnea)
you are experiencing bothersome hot flashes — at least 28 episodes over a two-week period that are severe enough to make you want treatment
you are willing to give yourself injections weekly
you are willing and able to follow a moderate calorie-restricted diet (about 500 calories below your normal intake) and exercise at least 150 minutes per week

You likely don't qualify if…

you have used hormone therapy or estrogen-containing treatments in the past 4 weeks
you have severe kidney disease or uncontrolled thyroid problems
you have had weight loss surgery or are planning to have weight loss surgery
you have been taking other weight-loss medications in the past 3 months
your weight has fluctuated significantly in recent months (more than 5% change in 3 months or 20+ pound swings in 6 months)

What participation looks like

You would be randomly assigned to receive either the medication or a placebo (inactive treatment) by injection once weekly for 24 weeks, along with personalized diet and exercise guidance. Throughout the study, you would track your hot flashes and complete regular check-ins to measure how you're doing. Researchers will also collect information about your health and aging to see if the medication makes a difference compared to the placebo group.

AI-generated summary from trial data · Aug 26, 2026 · Not medical advice

Trial locations(1 site)

United States

Mayo Clinic in Florida, Jacksonville, Florida