Plain-English translation of NCT07218445 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This is a pilot study testing whether —a medication that helps with weight loss—can also reduce hot flashes and improve signs of aging in postmenopausal women living with obesity. Researchers want to understand if this medication might help with two common problems that affect women after menopause: bothersome hot flashes and cellular aging. Half of the participants will receive the medication, and half will receive a placebo (a fake injection that looks identical).
Many postmenopausal women experience frequent, disruptive hot flashes that can affect daily life and sleep. Current treatment options are limited, and this medication might offer a new way to help. Researchers are also exploring whether the treatment could improve markers of biological aging in addition to managing hot flashes.
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You will participate in the study for 24 weeks (about 6 months). You will either receive weekly injections of the new medication or a placebo injection, plus standard advice about healthy eating and exercise. You'll need to commit to a moderate diet (cutting about 500 calories per day from your normal intake) and exercising at least 150 minutes per week. Throughout the study, you'll have clinic visits where researchers will track your hot flashes, measure your weight and health markers, and check how you're responding to the treatment.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
United States
Phase
Post-approval monitoring
Sponsor
Mayo Clinic
Enrollment target
~40 participants
Started
April 2026
Primary completion
September 2027
Age range
46 Years – 60 Years
Sex
Female only
Last updated on clinicaltrials.gov in June 2026.
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Central contact
Tina Taaffe
Mayo Clinic
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