Recruiting

Testing a New Treatment for Pustules on Hands and Feet

Plain-English translation of NCT07219420 on ClinicalTrials.gov ↗ · Source last updated August 2026 · Translation generated September 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This is a large research study testing a medication called to see if it can help treat palmoplantar pustulosis—a condition that causes painful, itchy pustules (small bumps filled with fluid) on your palms and soles of your feet. About 320 people will participate, and some will receive the medication while others receive a placebo (a dummy treatment with no active ingredient) at first, then switch to the real medication later in the study.

Palmoplantar pustulosis can be difficult to treat and cause significant discomfort and disability. This medication is designed to work against specific proteins in your immune system that may be driving the condition, so researchers want to see if this new treatment approach is safe and actually works better than a placebo.

Do you qualify?

You likely qualify if…

you are at least 18 years old
you have been diagnosed with palmoplantar pustulosis for at least 6 months
you have moderate to severe disease with pustules on your palms and/or soles (at least 5 active pustules)
you are a candidate for systemic therapy or light-based treatments (meaning your doctor believes you could safely receive these types of treatments)
you have not previously taken a similar type of medication called an IL-17 inhibitor

You likely don't qualify if…

you have other types of psoriasis (such as widespread pustular psoriasis) or similar skin conditions like atopic dermatitis or hand eczema
your symptoms improved significantly between your screening visit and start of the study
you are taking medications like beta blockers, certain blood pressure medications, lithium, or TNF inhibitors that may be causing or worsening your condition
you are currently taking or have previously taken this type of medication (IL-17 inhibitors, including bimekizumab)
you have skin lesions or other conditions that would make it difficult for doctors to fairly evaluate your pustules

What participation looks like

If you join this study, you will be randomly assigned to receive either the medication or a placebo injection. Those on placebo will switch to the real medication after an initial period. You'll visit the study center multiple times for check-ins where doctors will examine your hands and feet, ask about your symptoms, and monitor you for any side effects. The study includes an initial phase to test whether the medication works, followed by an extended period where participants continue treatment to see how well the medication maintains its effects.

AI-generated summary from trial data · Sep 2, 2026 · Not medical advice

Trial locations(91 sites)

United States

Ppp001 50754, Birmingham, Alabama

Ppp001 50176, Fremont, California

Ppp001 50746, Miami, Florida

Ppp001 50757, Auburn Hills, Michigan

Ppp001 50745, Columbus, Ohio