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Blocking brain blood vessels to treat severe chronic migraines

Plain-English translation of NCT07223008 on ClinicalTrials.gov ↗ · Source last updated May 2026 · Translation generated June 2026 · How we translate trials

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This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing a procedure called embolization using a product called Onyx to block two small blood vessels in the brain (the middle meningeal arteries) in people with severe chronic migraines that haven't responded to standard treatments. The theory is that by plugging these blood vessels, the brain releases fewer chemicals that trigger migraines. This treatment is not yet approved for migraines, though it is currently used for other brain conditions.

Many people with chronic migraines do not get relief from available medications, leaving them with persistent, disabling headaches. This trial is exploring whether this new approach — blocking specific blood vessels — might offer hope for patients who have already tried multiple standard migraine preventive treatments without success.

Do you qualify?

You likely qualify if…

you are between 18 and 80 years old
you have been diagnosed with chronic migraines (at least 15 headache days per month) that started before age 50
your migraines affect both sides of your head
you have tried and failed at least 2 different classes of migraine-prevention medications, or could not tolerate them
your chronic migraines have persisted for at least 12 months, with at least 6 months of symptoms after failing those medications
you have had at least one migraine-free day in the past month
your migraines significantly impact your daily life (a score of 21 or higher on the MIDAS disability scale)

You likely don't qualify if…

you have had previous brain or neck surgery, including vascular procedures or shunt placement
you have used opioid or barbiturate medications for migraine treatment in the past year
an MRI shows an abnormal brain lesion that might be causing your headaches
you have had radiation treatment to your head or neck
you have a history of serious allergies to contrast dye used during imaging (unless it can be managed with medication)
you have significant liver disease or serious kidney disease

What participation looks like

If you join this trial, you will undergo the embolization procedure, which uses special imaging to guide a tiny catheter to the target blood vessels in your brain where the Onyx material is injected to create a plug. Your participation will last about 8 months total, with 6 months of follow-up appointments after the procedure. You will need to keep a daily headache diary, continue taking your regular migraine medications, attend several clinic visits, and provide blood samples for research purposes.

AI-generated summary from trial data · Jun 1, 2026 · Not medical advice

Blocking brain blood vessels to treat severe chronic migraines

What is this trial?

Do you qualify?

What participation looks like

Trial locations