Plain-English translation of NCT07223242 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether tailored exercise training done at home—using video guides and weekly check-ins with a coach—can help people with a type of heart failure called HFpEF (where the heart's pumping strength looks normal but the heart isn't relaxing properly). You'll start with 3 months of moderate-intensity exercise, then depending on how you do, you may try adding resistance training, medication, or both for another 3 months.
Many people with this type of heart failure struggle with exercise and daily activities, which makes their condition worse and raises the risk of hospitalization or death. While supervised exercise training is known to help, it's hard for people to access because it requires trips to a gym or clinic. This study tests whether home-based exercise with virtual coaching could be an easier, more practical solution.
You likely qualify if…
You likely don't qualify if…
You'll start by doing 3 months of moderate-intensity exercise at home using tailored videos, with weekly virtual meetings with a coach to track your progress. Then you'll have a 3-month break to see what happens when you stop exercising. At the 6-month mark, if you continue, you'll be randomly assigned to one of four groups for another 3 months: exercise alone, exercise plus resistance training, exercise plus medication, or exercise plus resistance training plus medication.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
United States