Plain-English translation of NCT07224087 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing whether a combination approach—using two medications called Naltrexone and Bupropion together with counseling—can help people who smoke and are preparing for weight-loss surgery quit smoking while also losing weight. Many people planning this surgery smoke, and quitting is hard, especially when trying to lose weight at the same time. This study wants to see if treating both challenges together works better.
About 40% of people preparing for weight-loss surgery smoke, and quitting smoking often leads to weight gain—making it extra difficult to reach weight-loss goals before surgery. No one has tested a treatment designed specifically to help with both smoking and weight loss at the same time for this group of patients.
Over 4 months, you would take two medications daily and attend regular counseling sessions using cognitive-behavioral therapy—a type of talk therapy that helps you develop strategies to quit smoking and manage weight. The program combines the medication with behavioral support to address both smoking and weight loss at the same time. After the 4-month program ends, the study team will check how much weight you've lost and whether you've quit smoking.
AI-generated summary from trial data · Jul 19, 2026 · Not medical advice
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