Recruiting

Testing a hormone messenger to understand reproductive system function

Plain-English translation of NCT07224490 on ClinicalTrials.gov ↗ · Source last updated May 2026 · Translation generated June 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

What is this trial?

Researchers are studying how a hormone called kisspeptin affects the reproductive system's brain control center. This trial will give participants a single injection of kisspeptin and then take frequent blood samples to measure how the body responds. The study aims to understand how this hormone messenger works in both healthy people and those with long COVID.

Kisspeptin plays a crucial role in controlling reproductive hormones, but scientists don't fully understand how it works in people with long COVID or other reproductive disorders. This research could help explain why some people experience reproductive problems and guide future treatments.

Do you qualify?

You likely qualify if…

you are between 18–45 years old (if female) or 18–60 years old (if male)
you have normal blood pressure (below 140/90 mm Hg)
you have adequate hemoglobin levels in your blood
you are not currently taking hormonal medications or willing to stop them before the study
you have been diagnosed with post-COVID-19 syndrome, or you had COVID-19 in the past but did not develop long COVID (for the comparison group)

You likely don't qualify if…

you are pregnant, trying to become pregnant, or breast-feeding
you drink more than 10 alcoholic drinks per week or actively use illicit drugs
you have a history of blood clots, stroke, heart disease, cancer, or abnormal genital bleeding
you have a medical, mental, or behavioral condition that would prevent you from completing the study
you have had both ovaries removed

What participation looks like

You would visit the study site for one appointment lasting 1–2 hours. During your visit, researchers will give you a single injection of kisspeptin and then take blood samples every 10 minutes to measure how your body responds. The study involves one day of participation, making it a straightforward way to contribute to understanding how this hormone works.

AI-generated summary from trial data · Jun 9, 2026 · Not medical advice

Trial locations(1 site)

United States

Massachusetts General Hospital, Boston, Massachusetts