Plain-English translation of NCT07226232 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This is a large research study testing whether can help treat severe depression in U.S. military veterans who haven't gotten better with traditional antidepressant drugs. Researchers will give participants two doses of , spaced one month apart, along with professional support before, during, and after each session. The study will track how participants respond over 6 months to see if this treatment is safe and effective.
Many veterans struggle with depression that doesn't respond to standard antidepressants, sometimes combined with trauma-related stress. Early research suggests this medication might help people with treatment-resistant depression, but doctors need to study it carefully in veterans to understand whether it's truly safe and helpful for this group.
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If you join this study, you'll attend two main medication sessions — one month apart — where you'll receive the treatment in a supervised medical setting with professional support before and after each session. Between these visits and afterward, you'll have follow-up appointments where researchers will check how you're doing and ask about any changes in your mood or symptoms. The entire study lasts about 6 months, with more frequent check-ins in the first month and then longer intervals later on.
AI-generated summary from trial data · Aug 24, 2026 · Not medical advice
United States