Testing a new liver cancer treatment alone and in combination

Plain-English translation of NCT07227012 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated July 2026 · How we translate trials

Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.

What is this trial?

This trial is testing a new medication called to see if it can help treat hepatocellular carcinoma (a common type of liver cancer) that has advanced or spread and cannot be removed by surgery. You may receive the medication by itself or combined with another treatment called , which helps your immune system fight the cancer. The study will measure how safe the treatment is, how your body processes it, and whether it helps shrink or control the cancer.

Currently, treatment options for advanced liver cancer that cannot be removed surgically are limited. This trial exists to find out whether this new medication can offer patients like you a more effective option to slow or stop the growth of cancer.

Do you qualify?

You likely qualify if…

you are 18 years of age or older
you have been diagnosed with advanced or metastatic hepatocellular carcinoma that cannot be surgically removed
you have not received any prior chemotherapy or systemic treatments for your liver cancer
you have at least one measurable tumor that has not yet been treated
your liver, kidney, and overall health function are adequate to tolerate the treatment

You likely don't qualify if…

you have moderate to severe fluid buildup in your abdomen
you have a history of hepatic encephalopathy, a serious liver-related brain condition
you have cancer that has spread to your brain or spinal cord
you have had another cancer diagnosis within the past 3 years
you have active autoimmune diseases that require ongoing treatment

What participation looks like

You will receive the medication through IV infusions (injections directly into a vein) at a clinical trial site, where medical staff will monitor you during and after each visit. In the first phase of the study, researchers will gradually test different doses to find the safest and most effective level. In the second phase, you will be randomly assigned to receive either the medication alone or combined with another treatment. Throughout the study, you will have regular visits to assess how the treatment is working and monitor for any side effects.

AI-generated summary from trial data · Jul 10, 2026 · Not medical advice

Testing a new liver cancer treatment alone and in combination

What is this trial?

Do you qualify?

What participation looks like

Trial locations(49 sites)