Plain-English translation of NCT07227168 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a new medication called to see if it can help people whose cancer has continued to grow or come back after other treatments. The study will test by itself in some patients, and combined with an existing immunotherapy drug called in others. Researchers want to understand how safe this medication is, how the body processes it, and whether it can slow or shrink these cancers.
Many people with advanced cancers run out of treatment options because their cancer stops responding to standard therapies. This trial exists to explore whether this medication, which targets a protein called Tissue Factor found on cancer cells, might offer a new hope for patients who have exhausted other available treatments.
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This is a phase 1 trial designed in three parts: first, researchers will test increasing doses of the medication alone to find the right dose and watch for side effects; then, they may expand one dose level to more patients to confirm how well it works; finally, they may test the medication combined with in another group of patients. You would visit the clinic regularly for the medication, blood tests, scans to measure your tumor, and checkups to monitor your health and any side effects.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
United States