Plain-English translation of NCT07227363 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing whether nutritional ketosis—achieved either through a ketogenic diet or a ketone supplement—can help women with PCOS restore regular ovulation and improve their hormone balance. Polycystic ovary syndrome is a common condition that disrupts hormones, periods, and metabolism, and current treatments often only help with one symptom at a time. This research aims to see if ketogenic approaches might provide more comprehensive improvement.
Most PCOS treatments focus on managing individual symptoms rather than addressing the underlying hormonal and metabolic problems. Early research suggests that ketogenic diets may improve insulin sensitivity and hormone profiles, but very few studies have looked at whether this approach actually helps women ovulate regularly again.
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You will be randomly assigned to either follow a ketogenic diet (with meals provided for the first 2 weeks, then self-guided with dietitian support) or eat a regular balanced diet while taking a daily ketone supplement. For 12 weeks, you'll attend study visits for blood tests, hormone measurements, and imaging (including MRI scans), track your ovulation using a special monitor and daily finger-stick tests, and work with the study team to maintain your assigned dietary approach. The study will assess whether your menstrual cycle becomes more regular and your hormone levels improve.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
United States