Plain-English translation of NCT07227610 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
Brain tumors that spread from cancer elsewhere in your body can be hard to treat, especially when they're larger than 2 centimeters. This trial is testing two different ways to use focused radiation (called stereotactic radiosurgery) to treat these larger tumors. Both approaches aim to control the cancer while lowering the risk of side effects to healthy brain tissue.
Traditionally, doctors treated brain metastases with radiation to the whole brain, but this can damage memory and thinking. Focused radiation is better, but it's harder to get good results with larger tumors because doctors have to use lower doses to protect healthy brain tissue. This trial compares two focused radiation schedules to see which works better for these bigger tumors.
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If you enroll, you'll be randomly assigned to receive one of two radiation schedules. One group receives two focused radiation treatments 30 days apart, while the other group receives three daily treatments over 3 to 5 days. You'll need MRI scans for treatment planning, and your doctor will monitor you to track how well the treatment works and watch for any side effects. The study will follow you to see how your brain tumors respond over time.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
United States