Testing a new medication for moderate to severe inflammatory bowel disease

Plain-English translation of NCT07229950 on ClinicalTrials.gov ↗ · Source last updated June 2026 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This is a Phase 2 clinical trial testing a new medication called for patients with moderate to severe ulcerative colitis—a type of inflammatory bowel disease. The study will compare two different doses of the medication against a placebo (inactive pill) to see whether the treatment works and is safe. Researchers will also measure how the medication moves through your body.

Many people with ulcerative colitis don't respond well to current treatments, or they stop working over time. This trial aims to find out whether this new medication could offer another option for patients who need better control of their disease.

Do you qualify?

You likely qualify if…

you are between 18 and 75 years old
you have been diagnosed with ulcerative colitis for at least 90 days
you have moderate to severe active ulcerative colitis confirmed by recent endoscopy (camera test of your colon)
you have already tried at least one standard treatment (like 5-ASA, steroids, immunosuppressants, or biologic drugs) and it didn't work well enough, stopped working, or caused side effects you couldn't tolerate
you have a body mass index (BMI) of 18 or higher
you are willing and able to use effective birth control for the duration of the study plus 3 months afterward (if applicable)

You likely don't qualify if…

you have been diagnosed with Crohn's disease or indeterminate colitis instead of ulcerative colitis
you have never received any treatment for ulcerative colitis before
you have had recent severe infections, including C. difficile or other bowel infections within the past month, or you are currently taking antibiotics for an infection
you are currently taking or recently took certain immunosuppressant medications (like cyclosporine, mycophenolate, tacrolimus, or JAK inhibitors) within the past 4 weeks
you have had previous bowel surgery for ulcerative colitis or are likely to need surgery during the study

What participation looks like

You will visit the clinic for a screening period to confirm you qualify, then be randomly assigned to receive either a low dose of the medication, a high dose of the medication, or a placebo pill. You'll take your assigned treatment and have regular follow-up visits where doctors will check how you're doing, run blood tests, and possibly perform follow-up endoscopies to see if your colon has improved. The study includes a treatment period followed by a follow-up period to monitor your safety and how well the medication worked.

AI-generated summary from trial data · Jun 5, 2026 · Not medical advice

Trial locations(1 site)

China

West China Hospital of Sichuan University, Chengdu, Sichuan