Plain-English translation of NCT07232069 on ClinicalTrials.gov ↗ · Source last updated · Translation generated ·
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
PRE-EMPT is testing whether rosuvastatin (a statin that lowers cholesterol) and colchicine (an anti-inflammatory medication), alone or in combination, can slow the growth of soft plaque buildup in your heart arteries. You'll take one of four pill combinations daily for 2 years, and researchers will use imaging scans to see if the medication slows plaque growth.
Many people have early signs of heart disease without knowing it or having any symptoms. Doctors want to know if starting this medication early—before you have chest pain or a heart attack—can prevent the disease from getting worse.
You likely qualify if…
You likely don't qualify if…
You'll take two pills once daily at home—either the active medication, placebo, or a combination—for 2 years. You'll have heart imaging scans at the beginning and end of the study (done in person at a clinic), and all other visits will be virtual from home. You'll also collect some blood samples at home and receive support for healthy lifestyle changes like diet and exercise.
AI-generated summary from trial data · Aug 3, 2026 · Not medical advice
United States