Plain-English translation of NCT07240441 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
The EPISODE VT trial is testing whether treating dangerous heart rhythms after a heart attack works better when doctors ablate (burn away) abnormal tissue from both the inner and outer layers of the heart, rather than from the inner layer alone. Currently, most ablation procedures only treat the inner layer, but about half of patients experience the dangerous rhythms again. This trial will compare the two approaches in people who already have an implantable defibrillator protecting them.
After a heart attack, scar tissue can cause life-threatening irregular heartbeats that the defibrillator must treat with painful shocks. While ablation can help, treating only the inner heart layer misses abnormal tissue deeper in the heart muscle and on the outer surface, leading to high recurrence rates. This trial exists to see if reaching both the inner and outer layers stops these dangerous rhythms more effectively.
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If you join this trial, you will be randomly assigned to receive one of two ablation procedures: either treatment of the inner heart layer alone, or treatment of both the inner and outer layers using a special carbon dioxide technique to safely access the outer membrane. Both procedures use standard catheters and mapping systems your hospital already uses. You will be monitored to see how well the procedure works and whether your dangerous heartbeats come back.
AI-generated summary from trial data · Jul 7, 2026 · Not medical advice
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