Recruiting

Testing a new cancer drug alone and with an immune therapy

Plain-English translation of NCT07241039 on ClinicalTrials.gov ↗ · Source last updated May 2026 · Translation generated June 2026 · How we translate trials

What is this trial?

This trial is testing a new investigational medication called to see if it is safe and effective for treating advanced squamous cell cancers—cancers that develop in the flat cells lining the mouth, throat, lungs, or other areas. Researchers will test this medication both on its own and combined with another experimental drug called , which helps your immune system fight cancer. The study will involve about 220 patients across 40 sites worldwide over up to 5 years.

Currently, many patients with advanced squamous cell cancers run out of treatment options and have limited hope for a cure. This trial is exploring whether these new medications could offer benefit to patients whose cancers have stopped responding to standard treatments or who cannot tolerate them.

Do you qualify?

You likely qualify if…

you have been diagnosed with an advanced squamous cell cancer that has progressed despite standard treatment or for which no curative therapy is available
you have previously received immunotherapy drugs targeting PD-1 or PD-L1
you have tumor tissue available (either stored samples or are willing to provide a fresh biopsy) for research testing
you have measurable disease that can be tracked on scans and evaluated according to standard cancer response criteria
you are willing to attend regular clinic visits for assessments, blood tests, and imaging scans over the course of the study

You likely don't qualify if…

you have an active autoimmune disease (except vitiligo, type 1 diabetes, hypothyroidism, or psoriasis not requiring systemic treatment)
you have a history of a weakened immune system, bone marrow transplant, or solid organ transplant
you have received cancer treatment, radiation, or another investigational drug within the past 28 days
you are currently taking or have recently taken medications that interact with how your body processes this drug (like certain anti-fungal or antibiotic medications)
you consume grapefruit or grapefruit products, as these can interfere with how the medication works in your body

What participation looks like

You will visit a hospital or clinic regularly for check-ups, blood tests, and imaging scans throughout the study. Depending on which part of the trial you join, you will take the oral medication as a tablet by mouth, and possibly receive an intravenous infusion of the combination drug at a clinic. The study lasts up to 5 years, and you should expect more frequent visits and tests than you might receive in standard cancer care. Researchers will carefully monitor how the medication affects your cancer and watch for any side effects.

Testing a new cancer drug alone and with an immune therapy

What is this trial?

Do you qualify?

What participation looks like

Trial locations(12 sites)