Testing a glucose solution injected near knee nerves for arthritis pain

This trial is testing perineural prolotherapy—a treatment where a glucose solution (dextrose 5%) is injected around the small nerves that supply the knee joint—to see if it can reduce chronic pain from knee osteoarthritis. The treatment uses ultrasound guidance to place the injections precisely at four different nerves around the knee. Researchers believe the glucose solution may work by calming pain signals and reducing inflammation around these nerves, offering a gentler alternative to other pain treatments.

Standard treatments for knee arthritis pain have limited effectiveness and some can cause serious side effects. This trial exists to test whether this new approach—using a glucose solution injected around intact nerves—can safely and effectively reduce pain for people who have not found relief with other conservative treatments.