Understanding lung disease patterns in Chinese patients with bronchiectasis

Plain-English translation of NCT07245407 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated July 2026 · How we translate trials

What is this trial?

This is an observational study — meaning researchers will follow patients over time rather than test a new medication. The study aims to understand why bronchiectasis (a chronic lung disease causing permanent airway damage and frequent infections) develops differently in Chinese patients compared to patients in Europe and other countries. By collecting detailed medical information, lung function tests, and biological samples from Chinese bronchiectasis patients, researchers hope to discover the underlying biological reasons for these differences.

Bronchiectasis is becoming more common worldwide and causes significant suffering and healthcare burden. Recent research shows that Chinese patients have different disease patterns, causes, and outcomes than Western patients—for example, they experience more hospitalizations but fewer severe flare-ups. However, scientists don't yet understand the biological reasons behind these differences, which is important for developing better treatments tailored to Chinese patients.

Do you qualify?

You likely qualify if…

you have been diagnosed with non-cystic fibrosis bronchiectasis confirmed by CT scan and clinical symptoms like chronic cough and daily sputum production
you are age 18 or older (or age 30 or older if you are a healthy control)
you are able to perform lung function tests and use electronic monitoring devices
you can read and write in the language used at your study site and follow the study protocol
you are clinically stable at the time of enrollment (if you recently had a disease flare-up, you must wait at least 4 weeks before joining)

You likely don't qualify if…

you have cystic fibrosis, pulmonary fibrosis, or if your bronchiectasis is secondary to another lung disease like severe COPD or asthma
you have active cancer (except non-melanoma skin cancer) or unstable heart, kidney, liver, or other serious medical conditions
you have a history of significant drug or alcohol use in the past year
you have taken antibiotics for a respiratory infection in the past 4 weeks or currently have sinus infection
you are a current smoker or smoked within the past 3 months

What participation looks like

If you join, you will be part of a long-term observational study where researchers track your health over time through multiple visits to the study site. At these visits, you will complete lung function tests, answer health questionnaires, provide sputum or blood samples for testing, and possibly undergo a bronchoscopy (a procedure to look inside your airways). The study is designed to collect information about your disease patterns, the bacteria in your lungs, and biological markers that might explain why bronchiectasis develops differently in Chinese patients. Your specific visit schedule and duration will depend on the study protocol at your center.

AI-generated summary from trial data · Jul 15, 2026 · Not medical advice

Trial locations(38 sites)

China

Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, Beijing Municipality

Beijing Hospital, Beijing, Beijing Municipality

Peking University People's Hospital, Beijing, Beijing Municipality

The Second Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing Municipality

The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian