Testing two medications together versus one medication alone for lung heart disease with other health conditions

This trial is testing whether starting patients on two medications together—tadalafil and ambrisentan—works better than starting with just one medication (tadalafil) for treating pulmonary arterial hypertension (a serious condition where blood vessels in the lungs become too narrow, making the heart work harder). The study focuses on people who have this lung condition plus at least two other health problems like high blood pressure, diabetes, or heart disease. Researchers want to see if the two-drug approach helps more patients reach better health within six months compared to the single-drug approach.

We know that combining these two medications helps some patients with pulmonary arterial hypertension, but doctors don't yet know if this two-drug approach is safe and effective for people who also have other serious heart or metabolic conditions. This study will answer that question so doctors can make better treatment choices for their patients.