Recruiting

Testing a new weight loss medication alone and combined with existing treatment

Plain-English translation of NCT07245771 on ClinicalTrials.gov ↗ · Source last updated November 2025 · Translation generated June 2026 · How we translate trials

Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.

What is this trial?

This study is testing a new medication called to see if it can help adults with overweight or obesity lose weight and keep it off. Researchers will test the medication on its own and also combined with , a weight loss medication already available. The main goals are to check that the medication is safe, understand how your body processes it, and measure how much weight people lose.

Currently, there are only a few medications available for weight loss, and researchers want to develop new options that work well and are safe for more people. This trial aims to see whether this medication could become another tool to help people manage their weight and related health conditions like high blood pressure or high cholesterol.

Do you qualify?

You likely qualify if…

you have a BMI of 30 or higher (27.5 or higher if you have Asian ancestry), or a BMI of 27–30 (23–27.5 if you have Asian ancestry) with at least one weight-related health condition
your weight has been stable for the past 3 months (not gained or lost more than 5%)
you have high blood pressure, high cholesterol, or osteoarthritis — or none of these conditions if your BMI is in the obese range
your blood pressure is controlled at or below 140/90 mm Hg if you take blood pressure medication
you have not used other weight loss medications in the past 3 months

You likely don't qualify if…

you have gained or lost more than 5% of your body weight in the past 3 months
you have taken GLP-1 medications (a class of weight loss or diabetes drugs) within the past 6 months
you have had a bad reaction to GLP-1 medications in the past
you have diabetes or a blood sugar level (HbA1c) higher than 6.5%
you have significant liver disease or a history of cancer

What participation looks like

Participants will be divided into groups, with some receiving the new medication, some receiving a placebo (inactive pill), and some receiving combinations of treatments. Some participants will be healthy volunteers who take the medication alone, while others with overweight or obesity will test the medication combined with . You'll visit the research site multiple times for check-ins, blood tests, and weight measurements to monitor how well the medication works and whether it causes any side effects.

AI-generated summary from trial data · Jun 13, 2026 · Not medical advice

Trial locations(1 site)

Australia

Nucleus Network Pty Ltd, Melbourne, Victoria