Plain-English translation of NCT07246044 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a treatment called HD-tDCS (high-definition transcranial direct current stimulation)—a non-invasive way to stimulate a specific area of the brain involved in sensation and mood. Researchers want to see if this brain stimulation can help reduce depressive symptoms in teens and young adults with bipolar disorder. The study will also look for biological markers that might predict who will benefit most from the treatment.
Bipolar depression in young people is difficult to treat, and many available medications don't work well for everyone or come with unwanted side effects. This trial explores whether targeted brain stimulation could be a helpful addition to standard care.
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Over about 10 days, you would come in for 20 sessions of brain stimulation (two sessions per day, 20 minutes each). Half of participants will receive active stimulation, and half will receive sham (fake) stimulation—neither you nor the researchers will know which you're getting until the study ends. You'll also complete assessments including symptom questionnaires, memory and thinking tests, brain scans, blood draws, and monitoring of your sleep and voice patterns at the start, midway through, and after treatment. Your participation, including follow-up, could take around two years total, and all procedures and assessments are free.
AI-generated summary from trial data · Jun 8, 2026 · Not medical advice
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