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Testing a Special Eating Pattern to Support Healthy Aging

Plain-English translation of NCT07255300 on ClinicalTrials.gov ↗ · Source last updated December 2025 · Translation generated August 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing a dietary intervention called the fasting-mimicking diet (FMD)—a 5-day structured eating plan that mimics some of the beneficial effects of fasting without requiring you to stop eating entirely. Researchers want to see whether following this pattern three times per year can reduce belly fat, improve blood sugar control, lower heart disease risk factors, and slow signs of aging in your body.

Long-term fasting has shown promise for extending healthy lifespan in research, but it's too difficult and unsafe for most people to do. This treatment was developed to capture the same health benefits in a way that's realistic and safe for everyday adults to follow.

Do you qualify?

You likely qualify if…

you are between 30 and 65 years old
you are overweight or have other age-related health concerns like high blood pressure or elevated cholesterol
you have not had cancer, a heart attack, or stroke in the past 5 years
you are not pregnant
you are willing to follow the eating pattern three times in one year

You likely don't qualify if…

you have severe allergies to nuts (macadamia, cashew, almond, pecan), soy, oats, sesame, or celery
you are currently taking insulin or certain diabetes medications (other than metformin)
you have very high blood pressure (systolic over 200 or diastolic over 105) or unstable heart conditions
you have taken certain psychiatric medications, anti-anxiety medications, or seizure medications in the past 30 days
you have changed your regular medications, supplements, or over-the-counter drugs in the past 30 days or plan to do so during the study

What participation looks like

If you join, you will receive guidance on how to follow the fasting-mimicking diet and will complete it three times over the course of one year—roughly every four months. Each cycle involves eating specially designed meals for five days. You'll attend study visits where researchers measure your body composition, take blood samples to check biomarkers of aging and heart health, and monitor your overall health and well-being throughout the year.

AI-generated summary from trial data · Aug 6, 2026 · Not medical advice

Testing a Special Eating Pattern to Support Healthy Aging

What is this trial?

Do you qualify?

What participation looks like

Trial locations