Testing a New Medication for Job Syndrome With Lupus-like Disease or Eczema

Plain-English translation of NCT07262983 on ClinicalTrials.gov ↗ · Source last updated September 2026 · Translation generated September 2026 · How we translate trials

What is this trial?

This is a small pilot study testing a medication called in patients with Job syndrome—a rare immune system disorder—who also have lupus-like symptoms and/or severe eczema. Researchers want to see if the medication is safe to take and whether it helps reduce symptoms like skin flares and infections. The study will follow participants for about 6 months while they take the medication.

Job syndrome is a rare genetic disorder that makes it hard for the body to fight off certain infections and can cause severe skin and immune problems. Currently, there are limited treatment options for patients who also develop lupus-like symptoms or eczema on top of their Job syndrome. This study explores whether this medication might be a new, safer way to help these patients.

Do you qualify?

You likely qualify if…

you are at least 12 years old
you have been diagnosed with Job syndrome caused by a STAT3 gene mutation
you have lupus-like symptoms and/or severe eczema (EASI score of 16 or higher)
you are enrolled in an ongoing NIH natural history study of hyper-IgE syndrome
you can take pills by mouth and commit to following the study plan for 6 months
you are willing to use reliable birth control if you could become pregnant

You likely don't qualify if…

you are allergic to baricitinib or other JAK inhibitor medications
you have taken another experimental drug within the past 6 months
you are currently taking certain strong immune-suppressing medications like rituximab or methotrexate
you have taken part in another drug study and cannot commit to this one alone
you are unable to swallow pills or follow the medication schedule reliably

What participation looks like

You would start with a 3-month screening period where you track your infections and skin symptoms to make sure your disease is stable. If you qualify, you'll then take the medication by mouth for 6 months while coming in for regular check-ups. Researchers will watch closely for any side effects, check your infection rates, measure how your skin symptoms change, and ask you questions about how you're feeling and your quality of life.

Testing a New Medication for Job Syndrome With Lupus-like Disease or Eczema

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)