Testing a new injection for sciatic nerve pain

Plain-English translation of NCT07264270 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated June 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

What is this trial?

This is a Phase 1 safety study of , a new treatment for chronic sciatic nerve pain (sciatica). Researchers will inject the medication directly into the area around the nerve in the lower back using a specialized technique, and compare it to a placebo injection with saline. The goal is to understand how safe this treatment is and how well people tolerate it.

Many people with sciatic pain don't get enough relief from conservative treatments like physical therapy or oral medications. This trial explores whether delivering this medication directly to the affected nerve area might offer a safer, more effective option.

Do you qualify?

You likely qualify if…

you have chronic sciatic nerve pain (sciatica) that radiates down to or below your knee
your pain has not improved adequately despite trying standard treatments like physical therapy or medications
your body mass index is below 35 kg/m²
you are an adult willing to receive an injection in your lower back

You likely don't qualify if…

you have a bleeding disorder or take blood thinners or medications that affect platelet function
you have a history of certain mental health conditions including schizophrenia, bipolar disorder, or major depression
you have other nerve damage conditions such as diabetic neuropathy or autonomic neuropathy
you have had recent heart problems, including a heart attack within the last 6 months or heart failure
you have an active cancer or tumor, or have recently undergone back surgery

What participation looks like

You would be randomly assigned to receive either the new medication or a saline placebo as a single injection into the epidural space near your sciatic nerve. The injection is delivered using a specialized technique called transforaminal epidural administration, which targets the exact area where your nerve is being irritated. Researchers would monitor you closely to assess your safety and how well you tolerate the treatment.

AI-generated summary from trial data · Jun 7, 2026 · Not medical advice

Trial locations(3 sites)

Australia

Consano Bio Research Site, Broadmeadow, New South Wales

Consano Bio Research Site, Wahroonga, New South Wales

Consano Bio Research Site, Melbourne, Victoria