Different pain management approaches during colorectal cancer surgery

This trial is testing three different approaches to anesthesia and pain control during colorectal cancer surgery. Some patients will receive traditional opioid-based pain medication, others will receive a reduced amount of opioids combined with a nerve block, and others will receive no opioids at all. Researchers want to see which approach works best for pain control, recovery, and overall safety.

Opioids are powerful pain medications, but they can cause side effects and may affect how the body's immune system responds to cancer surgery. This study explores whether newer approaches that use fewer or no opioids might provide equal pain relief while improving safety and potentially supporting the body's natural defenses against cancer.